Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19701004 | 0.81 | NUDT1 (0.51) | MEN1NPC1RAB9AKMT2ATLR8 | |
| SCHEMBL5914036 | 0.79 | MEN1 (0.51) | MEN1NPC1RAB9AKMT2ALMNA | |
| SCHEMBL5676069 | 0.78 | NUDT1 (0.46) | MEN1NPC1RAB9AKMT2ATLR8 | |
| SCHEMBL28158326 | 0.77 | MEN1 (0.44) | MEN1NPC1RAB9AKMT2ATLR8 | |
| SCHEMBL1163079 | 0.77 | KMT2A (0.50) | MEN1NPC1RAB9AKMT2AHRH4 | |
| SCHEMBL27895804 | 0.77 | MEN1 (0.50) | MEN1NPC1RAB9AKMT2AMAPK14 | |
| SCHEMBL28158210 | 0.76 | MEN1 (0.49) | MEN1NPC1RAB9AKMT2AMAPK13 | |
| SCHEMBL171800 | 0.75 | HRH4 (0.46) | TLR8HRH4NUDT1KCNH2CACNA1C | |
| SCHEMBL28157934 | 0.74 | MEN1 (0.48) | MEN1NPC1RAB9AKMT2AHRH4 | |
| SCHEMBL1519145 | 0.73 | TLR8 (0.42) | TLR8HRH4NUDT1KCNH2CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464281-A1 | MUTANT IDH1 INHIBITORS | Eli Lilly and Company (US) | 2019-04-10 | — | — | EP | disclosed |
| CN-109311863-A | Saltant type IDH1 inhibitor | 伊莱利利公司 | 2019-02-05 | — | — | CN | disclosed |
| CN-108864081-A | Fgfr4 inhibitor and its preparation and application | 南京圣和药业股份有限公司 | 2018-11-23 | — | — | CN | disclosed |
| WO-2017213910-A1 | MUTANT IDH1 INHIBITORS | ELI LILLY AND COMPANY (US) | 2017-12-14 | — | — | WO | disclosed |
| EP-2521726-B1 | 5-OXO-5,8-DIHYDROPYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS CAMKII KINASES INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | SANOFI SA (FR) | 2013-12-18 | — | — | EP | disclosed |
| EP-2521726-A1 | 5-OXO-5, 8-DIHYDROPYRIDO [2, 3-D]PYRIMIDINE DERIVATIVES AS CAMKII KINASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES | SANOFI (FR) | 2012-11-14 | — | — | EP | disclosed |
| WO-2011086306-A9 | 5-OXO-5, 8-DIHYDROPYRIDO [2, 3-D] PYRIMIDINE DERIVATIVES AS CAMKII KINASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES | SANOFI-AVENTIS (FR) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011086306-A1 | 5-OXO-5, 8-DIHYDROPYRIDO [2, 3-D] PYRIMIDINE DERIVATIVES AS CAMKII KINASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | WO | disclosed |