Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 9/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12267064 | 0.76 | S1PR1 (0.66) | S1PR1PLATS1PR3TP53 | |
| SCHEMBL22280564 | 0.71 | S1PR1 (0.47) | S1PR1PLATNPC1RAB9ATSHR | |
| SCHEMBL30935604 | 0.71 | SMN1; SMN2 (0.42) | S1PR1SMN1; SMN2NPSR1TDP1SCN5A | |
| SCHEMBL13416797 | 0.69 | S1PR1 (1.00) | S1PR1NPSR1S1PR3TP53MAPT | |
| SCHEMBL14330924 | 0.68 | S1PR1 (1.00) | S1PR1S1PR3NPC1RAB9A | |
| SCHEMBL13416324 | 0.68 | S1PR1 (0.73) | S1PR1S1PR3NPC1RAB9A | |
| SCHEMBL19472922 | 0.68 | NPC1 (0.60) | S1PR1SMN1; SMN2PLATNPC1HTT | |
| SCHEMBL22280329 | 0.68 | SMN1; SMN2 (0.60) | SMN1; SMN2NPSR1TDP1SCN5ASCN10A | |
| SCHEMBL16202099 | 0.68 | S1PR1 (0.55) | S1PR1SMN1; SMN2TDP1S1PR3TP53 | |
| SCHEMBL30935486 | 0.68 | SCN5A (0.44) | S1PR1SMN1; SMN2NPSR1TDP1SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |