Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.47 |
| ▸ | PLAT | P00750 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280507 | 0.87 | CNR1 (0.46) | S1PR1PLATCNR1CNR2TLR9 | |
| Hydrochloric Acid SCHEMBL29523302 | 0.83 | SPHK1 (0.41) | TLR9TLR8TLR7 | |
| SCHEMBL22280458 | 0.81 | ALDH1A1 (0.54) | RAB9AALDH1A1TSHRRECQLNPC1 | |
| SCHEMBL22280454 | 0.81 | ALDH1A1 (0.54) | RAB9AALDH1A1TSHRRECQLNPC1 | |
| SCHEMBL22280455 | 0.76 | TLR9 (0.50) | S1PR1PLATTLR9TLR8TLR7 | |
| SCHEMBL22280440 | 0.74 | ALDH1A1 (0.55) | RAB9AALDH1A1TSHRRECQLNPC1 | |
| SCHEMBL22280635 | 0.74 | S1PR1 (0.54) | S1PR1PLATTLR9TLR8TLR7 | |
| SCHEMBL21387529 | 0.72 | KIT (0.49) | PLATCNR1CNR2TLR9TLR8 | |
| SCHEMBL12267064 | 0.71 | S1PR1 (0.66) | S1PR1PLATHDAC6LMNA | |
| SCHEMBL22280647 | 0.71 | S1PR1 (0.53) | S1PR1PLATRAB9ATSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |