SCHEMBL222813

SCHEMBL222813

CCNC(=O)Nc1nc2cc(-c3cncc(OC)c3)cc(Br)c2s1

nearest known ligand 0.68

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 13/20 0.68
PIK3CA P42336 10/20 0.68
ABL1 P00519 2/20 0.52
PIK3CD O00329 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL219571 0.89 PIK3CG (0.69) PIK3CGPIK3CAABL1PIK3CD
SCHEMBL2739670 0.87 PIK3CG (0.50) PIK3CGPIK3CAABL1PIK3CD
SCHEMBL2739702 0.84 PIK3CG (0.65) PIK3CGPIK3CAABL1
SCHEMBL220646 0.82 ABL1 (0.53) ABL1
SCHEMBL219641 0.81 PIK3CG (0.61) PIK3CGPIK3CAABL1
SCHEMBL222918 0.79 PIK3CA (0.46) PIK3CGPIK3CAABL1PIK3CD
SCHEMBL2739677 0.78 MAPK1 (0.49) PIK3CGPIK3CAABL1
SCHEMBL15260270 0.77 NPC1 (0.43) PIK3CGPIK3CAABL1PIK3CD
SCHEMBL222045 0.77 PIK3CA (0.50) PIK3CGPIK3CAABL1PIK3CD
SCHEMBL220904 0.77 NPC1 (0.54) PIK3CGPIK3CAABL1PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8481544-B2 Antibacterial compositions BIOTA EUROPE LIMITED (GB) 2013-07-09 US disclosed
US-8481544-B2 Antibacterial compositions BIOTA EUROPE LIMITED (GB) 2013-07-09 US disclosed
US-8389516-B2 Antibacterial compositions BIOTA EUROPE LIMITED (GB) 2013-03-05 US disclosed
US-8389516-B2 Antibacterial compositions BIOTA EUROPE LIMITED (GB) 2013-03-05 US disclosed
EP-2034997-B1 ANTIBACTERIAL COMPOSITIONS BIOTA EUROPE LTD (GB) 2012-10-17 EP disclosed
US-20120004221-A1 Antibacterial Compositions BIOTA EUROPE LIMITED (GB) 2012-01-05 US disclosed
US-20110263590-A1 Antibacterial Compositions BIOTA EUROPE LIMITED (GB) 2011-10-27 US disclosed
US-7977340-B2 Antibacterial compositions PROLYSIS LTD. (GB) 2011-07-12 US disclosed
US-7977340-B2 Antibacterial compositions PROLYSIS LTD. (GB) 2011-07-12 US disclosed
US-20090197877-A1 Antibacterial Compositions PROLYSIS LTD. (GB) 2009-08-06 US disclosed
US-20090197877-A1 Antibacterial Compositions PROLYSIS LTD. (GB) 2009-08-06 US disclosed
EP-2034997-A1 ANTIBACTERIAL COMPOSITIONS Prolysis Limited (GB) 2009-03-18 EP disclosed
WO-2007148093-A1 ANTIBACTERIAL COMPOSITIONS PROLYSIS LTD. (GB) 2007-12-27 WO disclosed
WO-2007148093-A1 ANTIBACTERIAL COMPOSITIONS PROLYSIS LTD. (GB) 2007-12-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120004221-A1 Antibacterial Compositions CYCS, COX6C, RPS6 PIK3CG 3492/4885PIK3CA 4048/4885ABL1 847/4885
US-20090197877-A1 Antibacterial Compositions CYCS, COX6C, INTS6 PIK3CG 2603/4885PIK3CA 3650/4885ABL1 1039/4885
US-20110263590-A1 Antibacterial Compositions CYCS, COX6C, RPS6 PIK3CG 3467/4885PIK3CA 4048/4885ABL1 931/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.