Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 8/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.36 |
| ▸ | GSK3A | P49840 | 6/20 | 0.36 |
| ▸ | GSK3B | P49841 | 6/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.36 |
| ▸ | PRKG1 | Q13976 | 5/20 | 0.36 |
| ▸ | PRKACA | P17612 | 5/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.36 |
| ▸ | PRKX | P51817 | 4/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.36 |
| ▸ | SGK2 | Q9HBY8 | 4/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22284238 | 1.00 | MAPK1 (0.39) | MAPK1MAPK3PKMHTTROCK1 | |
| SCHEMBL22284300 | 0.94 | ROCK2 (0.42) | MAPK1MAPK3PKMHTTROCK1 | |
| SCHEMBL30554287 | 0.94 | ROCK2 (0.42) | MAPK1MAPK3PKMHTTROCK1 | |
| SCHEMBL22284303 | 0.94 | ROCK2 (0.42) | MAPK1MAPK3PKMHTTROCK1 | |
| SCHEMBL30554317 | 0.93 | MAPK1 (0.40) | MAPK1MAPK3PKMHTTROCK1 | |
| SCHEMBL22284155 | 0.93 | MAPK1 (0.40) | MAPK1MAPK3PKMHTTROCK1 | |
| SCHEMBL22284153 | 0.93 | MAPK1 (0.40) | MAPK1MAPK3PKMHTTROCK1 | |
| SCHEMBL22284254 | 0.92 | PHGDH (0.39) | MAPK1MAPK3PKMHTTROCK1 | |
| SCHEMBL22284255 | 0.92 | PHGDH (0.39) | MAPK1MAPK3PKMHTTROCK1 | |
| SCHEMBL20920136 | 0.92 | MAPK1 (0.39) | MAPK1MAPK3PKMHTTROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3699179-A1 | PYRAZOLYL-CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. (CN) | 2020-08-26 | — | — | EP | disclosed |
| US-20200247815-A1 | PYRAZOLYL-CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI HANSOH BIOMEDICAL CO., LTD. (CN) | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247815-A1 | PYRAZOLYL-CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | MAPK1, MAPK11, MAPK14 | MAPK1 1/4885MAPK3 14/4885PKM 141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.