Sugi Predict

Sugi Predict / Compounds / SCHEMBL22285405

SCHEMBL22285405

SCHEMBL22285405

Cc1cncc(C(F)(F)C(=O)O)c1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ HCAR2 Q8TDS4 2/20 0.48
▸ ATM Q13315 1/20 0.41
▸ AGBL2 Q5U5Z8 1/20 0.36
▸ PGK1 P00558 1/20 0.35
▸ PGK2 P07205 1/20 0.35
▸ SCN10A Q9Y5Y9 1/20 0.34
▸ TAS2R14 Q9NYV8 2/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ SLC22A12 Q96S37 2/20 0.33
▸ GRB2 P62993 1/20 0.33
▸ HDAC4 P56524 1/20 0.32
▸ SMYD3 Q9H7B4 1/20 0.32
▸ CYP2C9 P11712 1/20 0.31
▸ CYP2C19 P33261 1/20 0.31
▸ CYP19A1 P11511 1/20 0.31
▸ PRMT5 O14744 1/20 0.31
▸ WDR77 Q9BQA1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26087549 0.78 PGK1 (0.45) AGBL2PGK1PGK2TAS2R14KDM4E
SCHEMBL15957705 0.78 PGK1 (0.50) AGBL2PGK1PGK2TAS2R14KDM4E
SCHEMBL1310273 0.76 HCAR2 (0.39) HCAR2ATMAGBL2SCN10ASLC22A12
SCHEMBL29427136 0.76 HCAR2 (0.39) HCAR2ATMAGBL2SCN10ASLC22A12
SCHEMBL15491237 0.74 HCAR2 (0.38) HCAR2ATMPGK1PGK2SLC22A12
SCHEMBL21958802 0.74 HCAR2 (0.38) HCAR2ATMPGK1PGK2SLC22A12
SCHEMBL31560767 0.72 PGK1 (0.40) PGK1PGK2TAS2R14SLC22A12GRB2
SCHEMBL8185345 0.72 PTPN5 (0.46) SLC22A12CYP2C9CYP2C19
SCHEMBL15957720 0.72 PGK1 (0.44) PGK1PGK2TAS2R14ALDH1A1SLC22A12
SCHEMBL26069685 0.72 HCAR2 (0.37) HCAR2ATMPGK1PGK2SLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12234225-B2 IL-17 ligands and uses thereof DICE ALPHA, INC. (US) 2025-02-25 — — US disclosed
CN-113874080-B IL-17A modulators and uses thereof 戴斯阿尔法公司 2024-09-27 — — CN disclosed
US-20230053746-A1 IL-17 LIGANDS AND USES THEREOF DICE MOLECULES SV, INC. 2023-02-23 — — US disclosed
US-11447468-B2 IL-17 ligands and uses thereof DICE ALPHA, INC. (US) 2022-09-20 — — US disclosed
EP-3921038-A1 IL-17A MODULATORS AND USES THEREOF Dice Alpha, Inc. (US) 2021-12-15 — — EP disclosed
WO-2020163554-A1 IL-17A MODULATORS AND USES THEREOF DICE ALPHA, INC. (US) 2020-08-13 — — WO disclosed
US-20200247785-A1 IL-17 Ligands And Uses Thereof DICE MOLECULES SV, INC. 2020-08-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230053746-A1 IL-17 LIGANDS AND USES THEREOF IL17A, IL2, IL15 HCAR2 368/4885ATM 3665/4885AGBL2 842/4885
US-11447468-B2 IL-17 ligands and uses thereof IL17A, IL2, IL15 HCAR2 368/4885ATM 3665/4885AGBL2 842/4885
US-20200247785-A1 IL-17 Ligands And Uses Thereof IL17A, IL2, IL15 HCAR2 368/4885ATM 3665/4885AGBL2 842/4885
US-12234225-B2 IL-17 ligands and uses thereof IL17A, IL2, IL15 HCAR2 368/4885ATM 3665/4885AGBL2 842/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.