Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 7/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22318100 | 0.90 | PDE3B (0.65) | PDE3BPDE3AHRH3PDE4APDE4B | |
| SCHEMBL22288541 | 0.90 | PDE3B (0.65) | PDE3BPDE3AHRH3PDE4APDE4B | |
| SCHEMBL22288540 | 0.85 | PDE3B (0.55) | PDE3BPDE3AHRH3PDE4APDE4B | |
| SCHEMBL22288562 | 0.85 | PDE3B (0.55) | PDE3BPDE3AHRH3PDE4APDE4B | |
| SCHEMBL22288543 | 0.85 | PDE3B (0.55) | PDE3BPDE3AHRH3PDE4APDE4B | |
| SCHEMBL22288550 | 0.79 | PDE3B (0.57) | PDE3BPDE3AGPR119 | |
| SCHEMBL22317378 | 0.78 | PDE3B (0.51) | PDE3BPDE3AHRH3PDE4APDE4B | |
| SCHEMBL22317982 | 0.76 | PDE3B (0.52) | PDE3BPDE3AHRH3S1PR1PDE4A | |
| SCHEMBL22288395 | 0.75 | PDE3B (0.60) | PDE3BPDE3AHRH3 | |
| SCHEMBL22307810 | 0.73 | CTSS (0.46) | PDE3BPDE3AS1PR1CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020157199-A1 | ANNULATED DIHYDROPYRIDAZINONE COMPOUNDS AS ANTI-CANCER COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020157199-A1 | ANNULATED DIHYDROPYRIDAZINONE COMPOUNDS AS ANTI-CANCER COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | disclosed |