Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.51 |
| ▸ | RXRB | P28702 | 4/20 | 0.51 |
| ▸ | RXRG | P48443 | 4/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22288724 | 0.89 | RXRA (0.53) | RXRARXRBRXRGMRGPRX4SMPD1 | |
| SCHEMBL3901919 | 0.83 | MRGPRX4 (0.69) | RXRARXRBRXRGMRGPRX4SMPD1 | |
| SCHEMBL1437991 | 0.80 | RXRA (0.61) | RXRARXRBRXRGMRGPRX4SMPD1 | |
| SCHEMBL3550858 | 0.80 | RXRA (0.57) | RXRARXRBRXRGMRGPRX4NPC1 | |
| SCHEMBL79709 | 0.80 | RXRA (0.72) | RXRARXRBRXRGMRGPRX4MEN1 | |
| SCHEMBL22308853 | 0.80 | BRD4 (0.61) | RXRARXRBRXRGMRGPRX4SMPD1 | |
| SCHEMBL2950475 | 0.78 | RXRA (0.59) | RXRARXRBRXRGMRGPRX4SMPD1 | |
| SCHEMBL22309140 | 0.78 | PTPN7 (0.55) | HDAC8SMN1; SMN2PPARDPTPN7DUSP3 | |
| SCHEMBL10323581 | 0.78 | RXRA (0.61) | RXRARXRBRXRGMRGPRX4SMPD1 | |
| SCHEMBL22288718 | 0.78 | NOTUM (0.49) | NPC1RAB9ASMN1; SMN2PTPN7DUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020157189-A1 | 1,2,4-TRIAZIN-6(1H)-ONE COMPOUNDS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020157189-A1 | 1,2,4-TRIAZIN-6(1H)-ONE COMPOUNDS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | disclosed |