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Sugi Predict / Compounds / SCHEMBL222889

SCHEMBL222889

SCHEMBL222889

O=c1cc(Cl)c2c3c(ccc2[nH]1)N(CC(F)(F)F)[C@@H](C(F)(F)F)CO3

nearest known ligand 0.63

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ AR P10275 20/20 0.63
▸ NR3C1 P04150 2/20 0.63
▸ PGR P06401 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL222890 1.00 AR (0.63) ARNR3C1PGR
SCHEMBL5118400 0.88 AR (0.79) ARNR3C1PGR
SCHEMBL223900 0.88 AR (0.78) ARNR3C1PGR
SCHEMBL11963022 0.88 AR (0.78) ARNR3C1PGR
SCHEMBL221554 0.86 AR (0.52) ARNR3C1PGR
SCHEMBL221555 0.86 AR (0.52) ARNR3C1PGR
SCHEMBL222841 0.86 AR (0.52) ARNR3C1PGR
SCHEMBL223233 0.86 AR (0.80) ARNR3C1PGR
SCHEMBL224497 0.86 AR (0.80) ARNR3C1PGR
SCHEMBL223259 0.77 AR (0.59) ARNR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130184206-A1 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2013-07-18 — — US claimed
US-20120004220-A9 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2012-01-05 — — US claimed
US-20100256129-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED 2010-10-07 — — US claimed
US-11358931-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2022-06-14 — — US disclosed
US-20200361866-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2020-11-19 — — US disclosed
US-10730831-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2020-08-04 — — US disclosed
US-20190040006-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2019-02-07 — — US disclosed
US-9675583-B2 Selective androgen receptor modulators (SARMS) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2017-06-13 — — US disclosed
US-20160038461-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2016-02-11 — — US disclosed
US-9139520-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2015-09-22 — — US disclosed
US-20140350065-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED (US) 2014-11-27 — — US disclosed
US-8748633-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2014-06-10 — — US disclosed
US-20130184206-A1 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2013-07-18 — — US disclosed
EP-2222636-B1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARM INC (US) 2013-04-10 — — EP disclosed
US-8354446-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2013-01-15 — — US disclosed
EP-2489656-A1 Selective androgen receptor modulators (sarms) and uses thereof Ligand Pharmaceuticals Inc. (US) 2012-08-22 — — EP disclosed
US-20120004220-A9 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2012-01-05 — — US disclosed
US-20100256129-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED 2010-10-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130184206-A1 Selective androgen receptor modulators (SARMs) and uses thereof AR, NR5A1, SHBG AR 1/4885NR3C1 26/4885PGR 92/4885
US-20200361866-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885NR3C1 26/4885PGR 92/4885
US-20100256129-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885NR3C1 31/4885PGR 97/4885
US-11358931-B2 Selective androgen receptor modulators (SARMs) and uses thereof AR, NR5A1, SHBG AR 1/4885NR3C1 31/4885PGR 82/4885
US-20160038461-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885NR3C1 26/4885PGR 92/4885
US-20190040006-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885NR3C1 26/4885PGR 92/4885
US-20140350065-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885NR3C1 26/4885PGR 92/4885
US-10730831-B2 Selective androgen receptor modulators (SARMs) and uses thereof AR, NR5A1, SHBG AR 1/4885NR3C1 31/4885PGR 82/4885
US-20120004220-A9 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885NR3C1 31/4885PGR 97/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.