Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 1/20 | 0.56 |
| ▸ | CCNH | P51946 | 1/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.56 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2228941 | 1.00 | FFAR1 (0.56) | FFAR1CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL2228937 | 1.00 | FFAR1 (0.56) | FFAR1CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL7568797 | 0.84 | P2RY2 (0.42) | FFAR1CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL7637263 | 0.84 | P2RY2 (0.42) | FFAR1CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL7569209 | 0.78 | BRD4 (0.43) | MAPTLMNAALDH1A1BRD4 | |
| SCHEMBL8359192 | 0.76 | PLA2G7 (0.38) | MAPTMEN1KMT2ALMNANPSR1 | |
| SCHEMBL5441050 | 0.76 | PLA2G7 (0.38) | MAPTMEN1KMT2ALMNANPSR1 | |
| SCHEMBL23928582 | 0.71 | MEN1 (0.71) | FFAR1CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL10514960 | 0.70 | MAPT (0.58) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL29599829 | 0.70 | MEN1 (0.55) | FFAR1CDK1CCNB1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |
| EP-2182953-A2 | NEW PYRAZOL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009013211-A2 | NEW PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | WO | disclosed |