Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.64 |
| ▸ | FLT3 | P36888 | 7/20 | 0.64 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.64 |
| ▸ | CDK1 | P06493 | 3/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.59 |
| ▸ | CDK7 | P50613 | 2/20 | 0.59 |
| ▸ | CCNH | P51946 | 2/20 | 0.59 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.59 |
| ▸ | IGF1R | P08069 | 3/20 | 0.58 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.58 |
| ▸ | CLK2 | P49760 | 2/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.58 |
| ▸ | CLK1 | P49759 | 1/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.58 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.58 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2227986 | 0.91 | CCNT1 (0.54) | CDK2FLT3CCNE1CDK1CCNB1 | |
| SCHEMBL2227077 | 0.86 | JAK2 (0.55) | CDK2FLT3CCNE1CDK1CCNB1 | |
| SCHEMBL13425095 | 0.85 | ABL1 (0.55) | CDK2FLT3CCNE1IGF1RDYRK1B | |
| SCHEMBL2227344 | 0.84 | DYRK1A (0.57) | CDK2CDK1CCNB1DYRK1AGSK3B | |
| SCHEMBL2226903 | 0.83 | ABL1 (0.53) | CDK2DYRK1AGSK3BCDK4CDK9 | |
| SCHEMBL2227731 | 0.83 | MKNK1 (0.51) | CDK2FLT3CCNE1CDK1CCNB1 | |
| SCHEMBL2229592 | 0.83 | MKNK1 (0.49) | CDK2FLT3CCNE1CDK1CCNB1 | |
| SCHEMBL2226553 | 0.83 | MKNK1 (0.49) | CDK2FLT3CCNE1IGF1RDYRK1B | |
| SCHEMBL2227770 | 0.82 | GSK3B (0.53) | CDK2FLT3CCNE1CDK1CCNB1 | |
| SCHEMBL2227684 | 0.82 | CDK2 (0.52) | CDK2FLT3CDK1CCNB1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183975-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | GOTO YASUHIRO | 2011-07-28 | — | — | US | disclosed |
| US-20110183975-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | GOTO YASUHIRO | 2011-07-28 | — | — | US | disclosed |
| US-20110183975-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | GOTO YASUHIRO | 2011-07-28 | — | — | US | disclosed |
| WO-2010042337-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183975-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | BRIX1, REL, CNKSR1 | CDK2 381/4885FLT3 925/4885CCNE1 582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.