Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | ANPEP | P15144 | 1/20 | 0.46 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.42 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1271959 | 1.00 | TACR1 (0.49) | TACR1POLBOPRK1MMEANPEP | |
| SCHEMBL1067140 | 0.99 | TACR1 (0.51) | TACR1POLBOPRK1MMEANPEP | |
| SCHEMBL1065803 | 0.99 | TACR1 (0.51) | TACR1POLBOPRK1MMEANPEP | |
| Hydrochloric Acid SCHEMBL11440859 | 0.99 | TACR1 (0.48) | TACR1POLBOPRK1MMEANPEP | |
| SCHEMBL1070524 | 0.93 | ERAP2 (0.47) | TACR1POLBMMEANPEPERAP2 | |
| SCHEMBL1069008 | 0.92 | IL1RN (0.46) | ERAP2ERAP1CTSLCTSBCTSS | |
| SCHEMBL1068982 | 0.91 | OPRK1 (0.48) | TACR1POLBOPRK1OPRD1OPRM1 | |
| SCHEMBL1068948 | 0.91 | OPRK1 (0.48) | TACR1POLBOPRK1OPRD1OPRM1 | |
| SCHEMBL1070478 | 0.90 | OPRK1 (0.58) | OPRK1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1069413 | 0.90 | OPRK1 (0.58) | OPRK1HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3917504-A1 | COMPOSITIONS AND METHODS FOR TREATING OR LIMITING DEVELOPMENT OF AGE-RELATED MACULAR DEGENERATION | Arizona Board of Regents on behalf of the University of Arizona (US) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020160256-A1 | COMPOSITIONS AND METHODS FOR TREATING OR LIMITING DEVELOPMENT OF AGE-RELATED MACULAR DEGENERATION | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2020-08-06 | — | — | WO | disclosed |