Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.81 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | SGK1 | O00141 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22290726 | 1.00 | SMARCA2 (0.81) | SMARCA2SMARCA4CYP3A4CYP2C9ROCK1 | |
| SCHEMBL22291060 | 0.95 | SMARCA2 (0.74) | SMARCA2SMARCA4CYP3A4CYP2C9ROCK1 | |
| SCHEMBL22291062 | 0.95 | SMARCA2 (0.74) | SMARCA2SMARCA4CYP3A4CYP2C9ROCK1 | |
| SCHEMBL22290945 | 0.92 | SMARCA2 (0.77) | SMARCA2SMARCA4CYP3A4CYP2C9ROCK1 | |
| SCHEMBL22290947 | 0.92 | SMARCA2 (0.77) | SMARCA2SMARCA4CYP3A4CYP2C9ROCK1 | |
| SCHEMBL22290758 | 0.92 | SMARCA2 (0.69) | SMARCA2SMARCA4CYP3A4CYP2C9ROCK1 | |
| SCHEMBL22290759 | 0.92 | SMARCA2 (0.69) | SMARCA2SMARCA4CYP3A4CYP2C9ROCK1 | |
| SCHEMBL22290416 | 0.92 | SMARCA2 (0.78) | SMARCA2SMARCA4CYP3A4CYP2C9ROCK1 | |
| SCHEMBL22290592 | 0.91 | SMARCA2 (0.80) | SMARCA2SMARCA4CYP3A4CYP2C9ROCK1 | |
| SCHEMBL22290589 | 0.91 | SMARCA2 (0.80) | SMARCA2SMARCA4CYP3A4CYP2C9ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3917527-B1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC (US) | 2025-04-23 | — | — | EP | disclosed |
| US-20230079819-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-03-16 | — | — | US | disclosed |
| EP-3917527-A1 | COMPOUNDS AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2021-12-08 | — | — | EP | disclosed |
| CN-113645971-A | Compound and use thereof | 福宏治疗公司 | 2021-11-12 | — | — | CN | disclosed |
| WO-2020160180-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020160180-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230079819-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | SMARCA2 14/4885SMARCA4 6/4885CYP3A4 3718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.