Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.58 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | SGK1 | O00141 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.45 |
| ▸ | DMPK | Q09013 | 1/20 | 0.45 |
| ▸ | MYLK | Q15746 | 1/20 | 0.45 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 4/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22290676 | 0.92 | SMARCA2 (0.53) | SMARCA2SMARCA4ROCK1ROCK2SGK1 | |
| SCHEMBL22290324 | 0.91 | SMARCA2 (0.52) | SMARCA2SMARCA4ROCK1ROCK2SGK1 | |
| SCHEMBL22290849 | 0.91 | SMARCA2 (0.48) | SMARCA2SMARCA4ROCK1ROCK2SGK1 | |
| SCHEMBL22290657 | 0.91 | SMARCA2 (0.50) | SMARCA2SMARCA4ROCK1ROCK2SGK1 | |
| SCHEMBL31173252 | 0.91 | SMARCA2 (0.57) | SMARCA2SMARCA4ROCK1CYP3A4CYP2C9 | |
| SCHEMBL22290432 | 0.91 | SMARCA2 (0.57) | SMARCA2SMARCA4ROCK1CYP3A4CYP2C9 | |
| SCHEMBL22290706 | 0.91 | SMARCA2 (0.57) | SMARCA2SMARCA4ROCK1CYP3A4CYP2C9 | |
| SCHEMBL22290581 | 0.90 | SMARCA2 (0.55) | SMARCA2SMARCA4ROCK1CYP3A4CYP2C9 | |
| SCHEMBL22290644 | 0.89 | SMARCA2 (0.56) | SMARCA2SMARCA4ROCK1ROCK2SGK1 | |
| SCHEMBL30058704 | 0.89 | SMARCA2 (0.56) | SMARCA2SMARCA4ROCK1ROCK2SGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3917527-B1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC (US) | 2025-04-23 | — | — | EP | disclosed |
| US-20230079819-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-03-16 | — | — | US | disclosed |
| EP-3917527-A1 | COMPOUNDS AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2021-12-08 | — | — | EP | disclosed |
| CN-113645971-A | Compound and use thereof | 福宏治疗公司 | 2021-11-12 | — | — | CN | disclosed |
| WO-2020160180-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020160180-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230079819-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | SMARCA2 14/4885SMARCA4 6/4885ROCK1 4248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.