⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4273507 | 0.67 | — | — | |
| SCHEMBL428605 | 0.66 | — | — | |
| SCHEMBL26114664 | 0.66 | — | — | |
| SCHEMBL8021753 | 0.66 | IMPDH2 (0.39) | — | |
| SCHEMBL17725133 | 0.65 | — | — | |
| SCHEMBL8616571 | 0.62 | KMT2A (0.50) | — | |
| SCHEMBL4103523 | 0.62 | — | — | |
| SCHEMBL5051720 | 0.62 | — | — | |
| SCHEMBL13654073 | 0.62 | — | — | |
| SCHEMBL22606280 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260078131-A1 | PYRROLO-PYRIDAZINE INHIBITORS OF JAK2 | AJAX THERAPEUTICS INC (US) | 2026-03-19 | — | — | US | disclosed |
| EP-3917925-B1 | PYRAZOLOPYRIDINES AND TRIAZOLOPYRIDINES AS A2A / A2B INHIBITORS | INCYTE CORP (US) | 2024-03-13 | — | — | EP | disclosed |
| US-11884665-B2 | Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors | INCYTE CORPORATION (US) | 2024-01-30 | — | — | US | disclosed |
| US-20230033393-A1 | PYRAZOLOPYRIDINES AND TRIAZOLOPYRIDINES AS A2A / A2B INHIBITORS | INCYTE CORPORATION | 2023-02-02 | — | — | US | disclosed |
| US-11390624-B2 | Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors | INCYTE CORPORATION (US) | 2022-07-19 | — | — | US | disclosed |
| CN-113906022-A | Pyrazolopyridines and triazolopyridines as A2A/A2B inhibitors | 因赛特公司 | 2022-01-07 | — | — | CN | disclosed |
| EP-3917925-A1 | PYRAZOLOPYRIDINES AND TRIAZOLOPYRIDINES AS A2A / A2B INHIBITORS | Incyte Corporation (US) | 2021-12-08 | — | — | EP | disclosed |
| US-20200270244-A1 | PYRAZOLOPYRIDINES AND TRIAZOLOPYRIDINES AS A2A / A2B INHIBITORS | INCYTE CORPORATION | 2020-08-27 | — | — | US | disclosed |
| WO-2020159905-A1 | PYRAZOLOPYRIDINES AND TRIAZOLOPYRIDINES AS A2A / A2B INHIBITORS | INCYTE CORPORATION (US) | 2020-08-06 | — | — | WO | disclosed |