Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 15/20 | 0.73 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25942616 | 0.91 | AR (0.71) | ARNPC1RAB9ASMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL22263265 | 0.90 | AR (0.70) | ARNPC1RAB9ASMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL22263280 | 0.90 | AR (0.70) | ARNPC1RAB9ASMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL22263323 | 0.90 | AR (0.70) | ARNPC1RAB9ASMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL30219483 | 0.90 | AR (0.70) | ARNPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL17014743 | 0.87 | AR (0.60) | ARNPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL22263397 | 0.86 | AR (0.64) | ARNPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL28928391 | 0.86 | AR (0.64) | ARNPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL26458197 | 0.86 | AR (0.75) | ARNPC1RAB9ASMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL30219487 | 0.85 | AR (0.74) | ARNPC1RAB9ASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3917916-A1 | BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR | Montelino Therapeutics, Inc. (US) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020160295-A1 | BI-FUNCTIONAL COMPOUNDS AND METHODS FOR TARGETED UBIQUITINATION OF ANDROGEN RECEPTOR | MONTELINO THERAPEUTICS, LLC (US) | 2020-08-06 | — | — | WO | disclosed |