Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 5/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | PPM1A | P35813 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22034130 | 0.98 | ACHE (0.68) | ACHEKDM4EHTTALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6231073 | 0.97 | ACHE (0.67) | ACHEKDM4EHTTALDH1A1MAPT | |
| Iodide SCHEMBL10815828 | 0.88 | ACHE (0.66) | ACHEKDM4EHTTALDH1A1MAPT | |
| Iodide SCHEMBL17187192 | 0.83 | KDM4E (0.65) | ACHEKDM4EHTTALDH1A1CYP1A2 | |
| SCHEMBL10814162 | 0.80 | ACHE (0.62) | ACHEKDM4EHTTALDH1A1MAPT | |
| Bromide SCHEMBL29389671 | 0.80 | KDM4E (0.61) | ACHEKDM4EHTTALDH1A1CYP1A2 | |
| SCHEMBL30914704 | 0.79 | ACHE (0.60) | ACHEBCHE | |
| Bromide SCHEMBL10812845 | 0.79 | ACHE (0.60) | ACHEKDM4EHTTALDH1A1MAPT | |
| Bromide SCHEMBL2340311 | 0.79 | ACHE (0.97) | ACHEKDM4EHTTALDH1A1CYP1A2 | |
| SCHEMBL29425198 | 0.78 | ACHE (0.55) | ACHEKDM4EHTTALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1951329-A | In-vivo photosensitive blood kalium sensor and preparation method thereof | UNIV ZHONGSHAN HOSPITAL FUDAN (CN) | 2007-04-25 | — | — | CN | claimed |
| US-6662039-B2 | Measuring response to calcium influx with fluorescent indicator | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2003-12-09 | — | — | US | claimed |
| US-12571798-B2 | Cancer biomarkers and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2026-03-10 | — | — | US | disclosed |
| US-12332245-B2 | Cancer biomarkers and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-06-17 | — | — | US | disclosed |
| EP-3796002-B1 | CANCER BIOMARKERS AND METHODS OF USE THEREOF | UNIV CALIFORNIA (US) | 2023-11-22 | — | — | EP | disclosed |
| US-20230204591-A1 | CANCER BIOMARKERS AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-06-29 | — | — | US | disclosed |
| EP-3796002-A1 | CANCER BIOMARKERS AND METHODS OF USE THEREOF | The Regents of The University of California (US) | 2021-03-24 | — | — | EP | disclosed |
| US-10955345-B2 | Relating to remote sensing | BAE SYSTEMS PLC (GB) | 2021-03-23 | — | — | US | disclosed |
| US-10852201-B2 | Remote sensing | BAE SYSTEMS PLC (GB) | 2020-12-01 | — | — | US | disclosed |
| EP-3508854-A1 | CANCER BIOMARKERS AND METHODS OF USE THEREOF | The Regents of The University of California (US) | 2019-07-10 | — | — | EP | disclosed |
| EP-3173487-B1 | DEVICE FOR DETECTION OF HALOGENATED HYDROCARBONS | UNIV MASARYKOVA (CZ) | 2019-02-20 | — | — | EP | disclosed |
| US-20040033500-A1 | Excitatory glycine receptors and methods | THE BURNHAM INSTITUTE | 2004-02-19 | — | — | US | disclosed |
| US-20030092004-A1 | Excitatory glycine receptors and methods | LIPTON STUART A (US) | 2003-05-15 | — | — | US | disclosed |
| US-6544794-B1 | Frozen thin film sample in contact with water soluble gel containing indicator; exposure to light | SHISEIDO COMPANY, LTD. (JP) | 2003-04-08 | — | — | US | disclosed |
| WO-2003016479-A2 | EXCITATORY GLYCINE RECEPTORS AND METHODS | THE BURNHAM INSTITUTE (US) | 2003-02-27 | — | — | WO | disclosed |
| US-20030021810-A1 | Chlorotoxin inhibition of cell invasion, cancer metastasis, angiogenesis and tissue remodeling | UAB RESEARCH FOUNDATION, THE | 2003-01-30 | — | — | US | disclosed |
| WO-2003000203-A2 | CHLOROTOXIN INHIBITION OF CELL INVASION, CANCER METASTASIS, ANGIOGENESIS AND TISSUE REMODELING | UAB RESEARCH FOUNDATION (US) | 2003-01-03 | — | — | WO | disclosed |
| EP-1234878-A1 | USE OF DISEASE-ASSOCIATED GENE | Takeda Chemical Industries, Ltd. (JP) | 2002-08-28 | — | — | EP | disclosed |
| EP-1154261-A2 | Imaging of ion distribution in tissue | SHISEIDO COMPANY LIMITED (JP) | 2001-11-14 | — | — | EP | disclosed |
| WO-2001033219-A2 | ION CHANNEL PERMEABILITY | BIOFOCUS DISCOVERY LIMITED (GB) | 2001-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12571798-B2 | Cancer biomarkers and methods of use thereof | MKI67, BRCA1, CD68 | ACHE 4641/4885KDM4E 2190/4885HTT 4490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.