Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 20/20 | 0.69 |
| ▸ | F9 | P00740 | 1/20 | 0.53 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.53 |
| ▸ | KLK1 | P06870 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23049391 | 1.00 | F11 (0.69) | F11F9KLKB1KLK1 | |
| SCHEMBL22294345 | 0.90 | F11 (0.68) | F11F9KLKB1KLK1 | |
| SCHEMBL22294347 | 0.90 | F11 (0.68) | F11F9KLKB1KLK1 | |
| SCHEMBL23049445 | 0.90 | F11 (0.68) | F11F9KLKB1KLK1 | |
| SCHEMBL22294606 | 0.89 | F11 (0.56) | F11F9KLKB1KLK1 | |
| SCHEMBL22294476 | 0.88 | F11 (0.64) | F11KLK1 | |
| SCHEMBL23049160 | 0.84 | F11 (0.70) | F11F9KLKB1KLK1 | |
| SCHEMBL22294620 | 0.84 | F11 (0.56) | F11F9KLKB1KLK1 | |
| SCHEMBL22294504 | 0.84 | F11 (0.52) | F11F9KLKB1 | |
| SCHEMBL17557214 | 0.84 | F11 (0.52) | F11F9KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3786165-A1 | SYNTHETIC INTERMEDIATES FOR PRODUCING MACROCYCLES AS FACTOR XIA INHIBITORS | Bristol-Myers Squibb Company (US) | 2021-03-03 | — | — | EP | disclosed |
| EP-2534154-B1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-08-05 | — | — | EP | disclosed |