Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22296403 | 0.90 | CYP1A2 (0.44) | HTTTEAD3KMT2APOLBTDP1 | |
| SCHEMBL4000585 | 0.86 | HTT (0.52) | HTTLMNAALDH1A1KMT2APOLB | |
| SCHEMBL30831288 | 0.85 | ALDH1A1 (0.44) | TEAD3LMNAALDH1A1KMT2AMAPT | |
| SCHEMBL1591923 | 0.80 | — | — | |
| SCHEMBL505654 | 0.80 | ALDH1A1 (0.48) | TEAD3LMNAALDH1A1KMT2AMAPT | |
| SCHEMBL4246917 | 0.79 | ALDH1A1 (0.50) | TEAD3ALDH1A1KMT2APOLB | |
| SCHEMBL11127056 | 0.78 | CYP1A2 (0.46) | HTTLMNAALDH1A1POLBTDP1 | |
| SCHEMBL180337 | 0.76 | CYP1A2 (0.54) | HTTLMNAALDH1A1KMT2APOLB | |
| SCHEMBL149678 | 0.75 | — | — | |
| SCHEMBL22048426 | 0.74 | TDP1 (0.52) | HTTLMNAALDH1A1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689871-B1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| EP-3689871-A1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2020-08-05 | — | — | EP | disclosed |