Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 8/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 12/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22296385 | 1.00 | JAK3 (0.51) | JAK3JAK1BTKEGFR | |
| SCHEMBL22296219 | 1.00 | JAK3 (0.51) | JAK3JAK1BTKEGFR | |
| SCHEMBL22222678 | 0.95 | JAK3 (0.47) | JAK3JAK1BTKEGFR | |
| SCHEMBL22296280 | 0.95 | JAK3 (0.47) | JAK3JAK1BTKEGFR | |
| SCHEMBL15695604 | 0.90 | BTK (0.46) | JAK3JAK1BTK | |
| SCHEMBL23865962 | 0.84 | JAK3 (0.47) | JAK3JAK1BTKEGFR | |
| SCHEMBL22222613 | 0.84 | JAK3 (0.47) | JAK3JAK1BTKEGFR | |
| SCHEMBL21706961 | 0.84 | JAK3 (0.47) | JAK3JAK1BTKEGFR | |
| SCHEMBL22296380 | 0.84 | JAK3 (0.47) | JAK3JAK1BTKEGFR | |
| SCHEMBL22222691 | 0.84 | JAK3 (0.47) | JAK3JAK1BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133064-A1 | FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF MENIN-MLL INTERACTION | BIOMEA FUSION, INC. (US) | 2022-06-23 | — | — | WO | disclosed |
| EP-3689871-B1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| EP-3689871-A1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2020-08-05 | — | — | EP | disclosed |