Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.40 |
| ▸ | BTK | Q06187 | 7/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21186661 | 0.86 | BTK (0.39) | HRH3BTK | |
| SCHEMBL21707124 | 0.79 | BTK (0.38) | BTKJAK3EGFRSRC | |
| SCHEMBL25558018 | 0.74 | SRC (0.37) | BTKJAK3SRC | |
| SCHEMBL4916392 | 0.72 | USP30 (0.42) | — | |
| SCHEMBL2410020 | 0.72 | USP30 (0.42) | — | |
| SCHEMBL4916393 | 0.72 | USP30 (0.42) | — | |
| SCHEMBL22296243 | 0.72 | BTK (0.36) | HRH3BTKEGFR | |
| SCHEMBL22296241 | 0.71 | HRH3 (0.40) | HRH3 | |
| SCHEMBL30231523 | 0.70 | PARP1 (0.36) | HRH3BTKJAK3SRC | |
| SCHEMBL22881068 | 0.70 | SRC (0.33) | JAK3SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689871-A1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2020-08-05 | — | — | EP | disclosed |