Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 18/20 | 0.67 |
| ▸ | JAK3 | P52333 | 10/20 | 0.58 |
| ▸ | EGFR | P00533 | 7/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | ITK | Q08881 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22296211 | 0.86 | BTK (0.67) | BTKJAK3EGFR | |
| SCHEMBL22296415 | 0.84 | BTK (0.67) | BTKJAK3EGFRLCK | |
| SCHEMBL22296210 | 0.84 | BTK (0.67) | BTKJAK3EGFRLCK | |
| SCHEMBL21707079 | 0.80 | BTK (1.00) | BTKJAK3EGFR | |
| SCHEMBL22296400 | 0.78 | BTK (0.64) | BTKJAK3EGFRLCKITK | |
| SCHEMBL22296205 | 0.76 | BTK (0.58) | BTKJAK3EGFR | |
| SCHEMBL23865978 | 0.76 | BTK (0.68) | BTKJAK3EGFRLCKITK | |
| SCHEMBL22496924 | 0.74 | JAK3 (1.00) | BTKJAK3 | |
| SCHEMBL22496931 | 0.74 | JAK3 (1.00) | BTKJAK3 | |
| SCHEMBL22497055 | 0.72 | BTK (1.00) | BTKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689871-B1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| EP-3689871-A1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2020-08-05 | — | — | EP | disclosed |