Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.59 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.57 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL880015 | 0.85 | CYP4A11 (0.66) | CYP4A11CYP4F2LOXL2ALDH1A1TP53 | |
| SCHEMBL19922867 | 0.84 | CYP4A11 (0.64) | CYP4A11CYP4F2LOXL2ALDH1A1TP53 | |
| SCHEMBL12196964 | 0.81 | CYP4A11 (0.67) | CYP4A11CYP4F2LOXL2ALDH1A1TP53 | |
| SCHEMBL7607124 | 0.80 | CYP4A11 (0.72) | CYP4A11CYP4F2LOXL2ALDH1A1TP53 | |
| SCHEMBL8337316 | 0.79 | CYP4A11 (0.60) | CYP4A11CYP4F2LOXL2ALDH1A1TP53 | |
| SCHEMBL10609552 | 0.78 | CYP4A11 (0.74) | CYP4A11CYP4F2LOXL2ALDH1A1TP53 | |
| SCHEMBL8759220 | 0.77 | CYP4A11 (0.72) | CYP4A11CYP4F2LOXL2ALDH1A1TP53 | |
| SCHEMBL2653637 | 0.77 | CYP4A11 (0.67) | CYP4A11CYP4F2LOXL2ALDH1A1TP53 | |
| SCHEMBL5118351 | 0.76 | CYP4A11 (0.66) | CYP4A11CYP4F2LOXL2ALDH1A1TP53 | |
| SCHEMBL8759817 | 0.76 | LOXL2 (0.67) | CYP4A11CYP4F2LOXL2ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3510022-B1 | INDOLE DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2020-08-05 | — | — | EP | disclosed |