Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12973159 | 0.64 | — | — | |
| SCHEMBL18460801 | 0.63 | FYN (0.33) | — | |
| SCHEMBL12344970 | 0.63 | NQO1 (0.30) | — | |
| SCHEMBL29634235 | 0.63 | NOS2 (0.37) | — | |
| SCHEMBL22566280 | 0.59 | KDM4E (0.35) | KDM4EALDH1A1GAA | |
| SCHEMBL23969746 | 0.58 | — | — | |
| SCHEMBL14176499 | 0.58 | GAA (0.55) | KDM4EALDH1A1GAA | |
| SCHEMBL22692309 | 0.57 | KDM4E (0.65) | KDM4EALDH1A1POLB | |
| SCHEMBL7751165 | 0.57 | KDM4E (0.66) | KDM4EALDH1A1POLBGAA | |
| SCHEMBL20792017 | 0.56 | HRH4 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689868-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Arvinas Operations, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |