Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.44 |
| ▸ | STS | P08842 | 7/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 5/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | SHBG | P04278 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20131459 | 1.00 | RORC (0.44) | RORCSTSCA1CA2CA5A | |
| SCHEMBL20153576 | 0.93 | RORC (0.41) | RORCSTSCA1CA2CA5A | |
| SCHEMBL22297830 | 0.83 | RORC (0.52) | RORCSTSCA1CA2CA5A | |
| SCHEMBL22297799 | 0.81 | STS (0.42) | RORCSTSCA1CA2CA5A | |
| SCHEMBL22297487 | 0.80 | RORC (0.50) | RORCSTSCA1CA2CA5A | |
| SCHEMBL20131713 | 0.80 | RORC (0.50) | RORCSTSCA1CA2CA5A | |
| SCHEMBL20131962 | 0.80 | RORC (0.53) | RORCSTSCA1CA2CA5A | |
| SCHEMBL22297735 | 0.80 | RORC (0.53) | RORCSTSCA1CA2CA5A | |
| SCHEMBL22297842 | 0.80 | RORC (0.51) | RORCSTSCA1CA2CA5A | |
| SCHEMBL22297483 | 0.79 | RORC (0.52) | RORCSTSCA1CA2CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541786-B1 | TRICYCLIC SULFONES AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2020-08-05 | — | — | EP | disclosed |