Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 6/20 | 0.56 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.56 |
| ▸ | KDM5C | P41229 | 1/20 | 0.56 |
| ▸ | PDE9A | O76083 | 7/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20870607 | 0.83 | KDM5A (0.53) | KDM5AKDM5BKDM5CPDE9APARP1 | |
| SCHEMBL20870269 | 0.80 | KDM5A (0.57) | KDM5AKDM5BKDM5CPDE9ALMNA | |
| SCHEMBL22871667 | 0.79 | PDE9A (0.47) | KDM5AKDM5BKDM5CPDE9APARP1 | |
| SCHEMBL22871683 | 0.78 | PDE9A (0.67) | KDM5AKDM5BKDM5CPDE9APARP1 | |
| SCHEMBL20870599 | 0.78 | KDM5A (0.55) | KDM5AKDM5BKDM5CPDE9APARP1 | |
| SCHEMBL22298182 | 0.76 | KDM5A (0.56) | KDM5AKDM5BKDM5CPDE9APARP1 | |
| SCHEMBL22871658 | 0.76 | KDM5A (0.75) | KDM5AKDM5BKDM5CPDE9APARP1 | |
| SCHEMBL20870616 | 0.76 | KDM5A (0.59) | KDM5AKDM5BKDM5CPDE9APARP1 | |
| SCHEMBL22298103 | 0.75 | KDM5A (0.69) | KDM5AKDM5BKDM5CPDE9APARP1 | |
| SCHEMBL20870262 | 0.72 | KDM5A (1.00) | KDM5AKDM5BKDM5CPDE9APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689876-A1 | PDE9 INHIBITOR AND USE THEREOF | Nanjing Transthera Biosciences Co. Ltd. (CN) | 2020-08-05 | — | — | EP | disclosed |