Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 6/20 | 0.75 |
| ▸ | KDM5C | P41229 | 1/20 | 0.75 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.75 |
| ▸ | PDE9A | O76083 | 7/20 | 0.60 |
| ▸ | PARP1 | P09874 | 2/20 | 0.54 |
| ▸ | CHUK | O15111 | 2/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | TOP1 | P11387 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20870262 | 0.86 | KDM5A (1.00) | KDM5AKDM5CKDM5BPDE9APARP1 | |
| SCHEMBL22298103 | 0.86 | KDM5A (0.69) | KDM5AKDM5CKDM5BPDE9APARP1 | |
| SCHEMBL4754631 | 0.86 | KDM5A (0.69) | KDM5AKDM5CKDM5BPDE9APARP1 | |
| SCHEMBL14442482 | 0.82 | KDM5A (0.64) | KDM5AKDM5CKDM5BPDE9APARP1 | |
| SCHEMBL22298231 | 0.79 | PDE9A (0.80) | KDM5AKDM5CKDM5BPDE9A | |
| SCHEMBL23885176 | 0.78 | KDM5A (0.55) | KDM5AKDM5CKDM5BPDE9APARP1 | |
| SCHEMBL20870243 | 0.78 | PDE9A (0.79) | KDM5AKDM5CKDM5BPDE9A | |
| SCHEMBL20870616 | 0.78 | KDM5A (0.59) | KDM5AKDM5CKDM5BPDE9APARP1 | |
| SCHEMBL20870101 | 0.78 | PDE9A (0.79) | KDM5AKDM5CKDM5BPDE9A | |
| SCHEMBL20870269 | 0.77 | KDM5A (0.57) | KDM5AKDM5CKDM5BPDE9APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10889591-B2 | PDE9 inhibitor and use thereof | NANJING TRANSTHERA BIOSCIENCES CO. LTD. (CN) | 2021-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10889591-B2 | PDE9 inhibitor and use thereof | PDE3A, PDE9A, PDE3B | KDM5A 1199/4885KDM5C 2394/4885KDM5B 1464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.