Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 17/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
| ▸ | GABRD | O14764 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.38 |
| ▸ | GABRE | P78334 | 2/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20870149 | 0.87 | PDE9A (0.61) | PDE9AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL20870339 | 0.87 | PDE9A (0.61) | PDE9AGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL22298110 | 0.79 | PDE9A (0.84) | PDE9A | |
| SCHEMBL22298185 | 0.78 | PDE9A (0.60) | PDE9AKDM4E | |
| SCHEMBL20870152 | 0.77 | PDE9A (1.00) | PDE9A | |
| SCHEMBL24063446 | 0.76 | PDE9A (0.61) | PDE9A | |
| SCHEMBL22298117 | 0.75 | PDE9A (0.61) | PDE9AGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL20870562 | 0.73 | PDE9A (0.60) | PDE9AGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL20870280 | 0.73 | PDE9A (0.60) | PDE9AGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL28872522 | 0.71 | KDM5A (0.56) | PDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689876-A1 | PDE9 INHIBITOR AND USE THEREOF | Nanjing Transthera Biosciences Co. Ltd. (CN) | 2020-08-05 | — | — | EP | disclosed |