Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.53 |
| ▸ | F10 | P00742 | 4/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1975601 | 1.00 | RORC (0.53) | RORCF10PRSS1S1PR5S1PR1 | |
| SCHEMBL1713482 | 0.90 | RORC (0.55) | RORCF10S1PR5S1PR1SIGMAR1 | |
| SCHEMBL4162044 | 0.90 | RORC (0.55) | RORCF10S1PR5S1PR1SIGMAR1 | |
| SCHEMBL2782848 | 0.90 | RORC (0.55) | RORCF10S1PR5S1PR1SIGMAR1 | |
| SCHEMBL1975861 | 0.90 | RORC (0.55) | RORCF10S1PR5S1PR1SIGMAR1 | |
| SCHEMBL1344798 | 0.88 | RORC (0.53) | RORCF10PRSS1S1PR5S1PR1 | |
| SCHEMBL1345133 | 0.88 | RORC (0.53) | RORCF10PRSS1S1PR5S1PR1 | |
| SCHEMBL1975899 | 0.86 | RORC (0.59) | RORCF10PRSS1S1PR5DPP4 | |
| SCHEMBL2226818 | 0.86 | RORC (0.59) | RORCF10PRSS1S1PR5DPP4 | |
| SCHEMBL1713887 | 0.86 | RORC (0.51) | RORCS1PR5S1PR1SIGMAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513052-A1 | PYRROLIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011085886-A1 | PYRROLIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |