Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.75 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | IDH1 | O75874 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14073845 | 0.87 | CYP3A4 (0.82) | CYP3A4CYP19A1CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL18770356 | 0.86 | CYP3A4 (1.00) | CYP3A4CYP19A1CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL18770343 | 0.79 | CYP3A4 (0.80) | CYP3A4CYP19A1CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL14073594 | 0.78 | CYP2C9 (0.69) | CYP3A4CYP19A1CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL14073778 | 0.73 | CYP3A4 (0.61) | CYP3A4CYP19A1CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL30444601 | 0.73 | KMT2A (0.62) | CYP3A4CYP19A1CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL14073852 | 0.72 | CYP3A4 (0.61) | CYP3A4CYP19A1CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL22284864 | 0.72 | CYP3A4 (0.79) | CYP3A4CYP19A1CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL29478292 | 0.72 | CYP3A4 (0.79) | CYP3A4CYP19A1CYP2C9CYP1A2CYP2C19 | |
| SCHEMBL14073692 | 0.72 | ALDH1A1 (0.72) | CYP3A4CYP19A1CYP2C9CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200247794-A1 | PHARMACOPHORES, COMPOUNDS AND METHODS HAVING APPLICATION IN THE TREATMENT OF CANCER THROUGH INHIBITION OF CYP17A1 AND CYP19A1 | MANGOSUTHU UNIVERSITY TECHNOLOGY (ZA) | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247794-A1 | PHARMACOPHORES, COMPOUNDS AND METHODS HAVING APPLICATION IN THE TREATMENT OF CANCER THROUGH INHIBITION OF CYP17A1 AND CYP19A1 | CYP19A1, CYP26A1, CYP21A2 | CYP3A4 48/4885CYP19A1 1/4885CYP2C9 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.