SCHEMBL22299355

SCHEMBL22299355

CNc1cc(NCc2ccc(C(F)(F)F)cc2)ccc1NC(=O)CC(C)(C)C

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNQ3 O43525 3/20 0.62
KCNQ2 O43526 3/20 0.62
KCNQ4 P56696 1/20 0.48
KCNQ5 Q9NR82 1/20 0.48
FFAR1 O14842 1/20 0.46
PPARA Q07869 2/20 0.42
CTNNB1 P35222 3/20 0.41
TCF7L2 Q9NQB0 3/20 0.41
MTOR P42345 1/20 0.41
CSNK1D P48730 1/20 0.41
HTT P42858 2/20 0.41
LMNA P02545 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.40
HPGD P15428 2/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
MCHR1 Q99705 1/20 0.40
RORC P51449 1/20 0.40
HDAC3 O15379 1/20 0.40
HDAC1 Q13547 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22288442 0.87 KCNQ2 (0.68) KCNQ3KCNQ2KCNQ4KCNQ5FFAR1
SCHEMBL31577178 0.87 KCNQ2 (0.68) KCNQ3KCNQ2KCNQ4KCNQ5FFAR1
SCHEMBL22299365 0.83 KCNQ3 (0.62) KCNQ3KCNQ2KCNQ4KCNQ5FFAR1
SCHEMBL22299359 0.83 KCNQ3 (0.52) KCNQ3KCNQ2KCNQ4KCNQ5FFAR1
SCHEMBL22299434 0.83 KCNQ3 (0.58) KCNQ3KCNQ2KCNQ4KCNQ5FFAR1
SCHEMBL22299356 0.83 KCNQ3 (0.52) KCNQ3KCNQ2KCNQ4KCNQ5FFAR1
SCHEMBL31576842 0.81 KCNQ2 (0.58) KCNQ3KCNQ2KCNQ4KCNQ5FFAR1
SCHEMBL22299368 0.81 KCNQ3 (0.66) KCNQ3KCNQ2KCNQ4KCNQ5FFAR1
SCHEMBL22299453 0.81 KCNQ3 (0.55) KCNQ3KCNQ2KCNQ4KCNQ5FFAR1
SCHEMBL22299436 0.81 LDLR (0.50) FFAR1HTTSMN1; SMN2HPGDNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3917907-B1 MODULATORS OF POTASSIUM ION CHANNELS AND USES THEREOF UNIV DEGLI STUDI DI SALERNO (IT) 2025-05-21 EP claimed
EP-3917907-B1 MODULATORS OF POTASSIUM ION CHANNELS AND USES THEREOF UNIV DEGLI STUDI DI SALERNO (IT) 2025-05-21 EP disclosed
WO-2020157126-A1 MODULATORS OF POTASSIUM ION CHANNELS AND USES THEREOF Università degli Studi di Salerno (IT) 2020-08-06 WO disclosed