Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.74 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.74 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.74 |
| ▸ | MMP13 | P45452 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200725 | 0.85 | HDAC1 (1.00) | HDAC6HDAC1HDAC3HDAC4HPGD | |
| SCHEMBL4923598 | 0.85 | MMP13 (0.64) | MMP13HPGDALDH1A1KDM4EUSP2 | |
| SCHEMBL4928216 | 0.82 | KMT2A (0.68) | MMP13HPGDALDH1A1KDM4EUSP2 | |
| SCHEMBL2202586 | 0.82 | HDAC1 (0.72) | HDAC6HDAC1HDAC3HDAC4HPGD | |
| SCHEMBL2201189 | 0.81 | HDAC1 (0.71) | HDAC6HDAC1HDAC3HDAC4HPGD | |
| SCHEMBL17707613 | 0.81 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC4CYP2C9 | |
| SCHEMBL2290270 | 0.81 | HDAC6 (0.79) | HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL12496063 | 0.81 | MMP13 (0.61) | MMP13HPGDALDH1A1KDM4EUSP2 | |
| SCHEMBL2203317 | 0.80 | HDAC6 (0.65) | HDAC6HDAC1HDAC3HDAC4HPGD | |
| SCHEMBL2203242 | 0.79 | HDAC1 (0.79) | HDAC6HDAC1HDAC3HDAC4MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926721-B1 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | MSD ITALIA SRL (IT) | 2016-05-04 | — | — | EP | claimed |
| EP-1926721-B1 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | MSD ITALIA SRL (IT) | 2016-05-04 | — | — | EP | disclosed |
| US-7977374-B2 | Thiophene and thiazole substituted trifluoroethanone derivatives as histone deacetylase (HDAC) inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-07-12 | — | — | US | disclosed |
| US-20090156591-A1 | Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156591-A1 | Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors | HDAC1, HDAC2, HDAC11 | HDAC6 6/4885HDAC1 1/4885HDAC3 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.