Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 9/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 2/20 | 0.55 |
| ▸ | BACE1 | P56817 | 2/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22291145 | 0.84 | ENPP1 (0.69) | ENPP1MAPK1ACHEBACE1PDGFRB | |
| SCHEMBL11091971 | 0.83 | ENPP1 (0.68) | ENPP1MAPK1ACHEBACE1AURKA | |
| SCHEMBL11483724 | 0.83 | ENPP1 (0.62) | ENPP1MAPK1ACHEBACE1PDGFRB | |
| SCHEMBL22291036 | 0.82 | ENPP1 (0.72) | ENPP1MAPK1ACHEBACE1PDGFRB | |
| SCHEMBL20782445 | 0.81 | ENPP1 (0.74) | ENPP1MAPK1ACHEBACE1PDGFRB | |
| SCHEMBL22300102 | 0.79 | ENPP1 (0.78) | ENPP1MAPK1ACHEBACE1PDGFRB | |
| SCHEMBL22441523 | 0.79 | ENPP1 (0.71) | ENPP1MAPK1ACHEBACE1PDGFRB | |
| SCHEMBL10616287 | 0.79 | MAPK1 (0.64) | ENPP1MAPK1ACHEBACE1AURKA | |
| SCHEMBL31457638 | 0.79 | ENPP1 (0.59) | ENPP1MAPK1ACHEBACE1PDGFRB | |
| SCHEMBL4969189 | 0.79 | ENPP1 (0.82) | ENPP1MAPK1ACHEBACE1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020160333-A1 | ENPP1 INHIBITORS AND METHODS OF MODULATING IMMUNE RESPONSE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2020-08-06 | — | — | WO | disclosed |