Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 8/20 | 0.82 |
| ▸ | ACHE | P22303 | 7/20 | 0.66 |
| ▸ | BACE1 | P56817 | 7/20 | 0.66 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273796 | 0.90 | ENPP1 (1.00) | ENPP1ACHEBACE1PDE10AMAPK1 | |
| Hydrochloric Acid SCHEMBL7273812 | 0.89 | ENPP1 (0.98) | ENPP1ACHEBACE1PDE10AMAPK1 | |
| Hydrochloric Acid SCHEMBL22441606 | 0.89 | ENPP1 (0.98) | ENPP1ACHEBACE1PDE10AMAPK1 | |
| SCHEMBL20798259 | 0.88 | ENPP1 (0.76) | ENPP1ACHEBACE1PDE10AMAPK1 | |
| SCHEMBL30446314 | 0.88 | ENPP1 (0.76) | ENPP1ACHEBACE1PDE10AMAPK1 | |
| SCHEMBL10616850 | 0.87 | ENPP1 (0.74) | ENPP1ACHEBACE1PDE10AMAPK1 | |
| SCHEMBL22164790 | 0.87 | ENPP1 (0.74) | ENPP1ACHEBACE1PDE10AMAPK1 | |
| SCHEMBL30776977 | 0.87 | ENPP1 (0.74) | ENPP1ACHEBACE1PDE10AMAPK1 | |
| SCHEMBL10908319 | 0.87 | ENPP1 (0.74) | ENPP1ACHEBACE1PDE10AMAPK1 | |
| SCHEMBL10912799 | 0.87 | ENPP1 (0.74) | ENPP1ACHEBACE1PDE10AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899319-A2 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1893206-A2 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-05 | — | — | EP | disclosed |
| US-20070004763-A1 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-04 | — | — | US | disclosed |
| US-20070004763-A1 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-04 | — | — | US | disclosed |
| US-20070004763-A1 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-04 | — | — | US | disclosed |
| WO-2006135649-A2 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |
| WO-2006135636-A2 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |
| US-20060281771-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-12-14 | — | — | US | disclosed |
| US-4668683-A | Cardiotonic quinazoline derivatives | KYOWA HAKKO KOGYO K.K. (JP) | 1987-05-26 | — | — | US | disclosed |
| EP-0195667-A2 | Cardiotonic quinazoline derivatives | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1986-09-24 | — | — | EP | disclosed |
| US-4188391-A | 4-[4-(Substituted)piperidino]quinazoline cardiac stimulants | PFIZER INC. (US) | 1980-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281771-A1 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | FLT3, CDC42BPG, PRKCQ | ENPP1 1922/4885ACHE 4844/4885BACE1 2096/4885 |
| US-20070004763-A1 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | FLT3, BMX, ABL1 | ENPP1 2497/4885ACHE 4535/4885BACE1 2700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.