Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.38 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18319891 | 0.90 | KMT2A (0.39) | THRBTSHRL3MBTL1GSTP1GSTM2 | |
| SCHEMBL29187790 | 0.86 | HPGD (0.42) | THRBL3MBTL1MAPK1HPGDNAMPT | |
| SCHEMBL22493634 | 0.86 | PTPN11 (0.37) | GSTP1GSTM2KMT2APRNPPOLB | |
| SCHEMBL24034328 | 0.86 | THRB (0.43) | THRBTSHRL3MBTL1MAPK1GSTP1 | |
| SCHEMBL23901946 | 0.81 | TSHR (0.41) | THRBTSHRL3MBTL1MAPK1HPGD | |
| SCHEMBL23901922 | 0.81 | THRB (0.38) | THRBTSHRL3MBTL1HPGDKMT2A | |
| SCHEMBL19785529 | 0.80 | KMT2A (0.35) | THRBL3MBTL1MAPK1GSTP1GSTM2 | |
| SCHEMBL29506060 | 0.77 | KMT2A (0.45) | GSTP1GSTM2KMT2APRNPPOLB | |
| SCHEMBL18319841 | 0.77 | KMT2A (0.45) | GSTP1GSTM2KMT2APRNPPOLB | |
| SCHEMBL19785381 | 0.77 | GRM4 (0.40) | GSTP1GSTM2KMT2APRNPPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118206550-A | SHP2 inhibitor and application thereof | 江苏威凯尔医药科技有限公司 | 2024-06-18 | — | — | CN | disclosed |
| WO-2020156243-A1 | SHP2 INHIBITOR AND APPLICATION THEREOF | 贝达药业股份有限公司 | 2020-08-06 | — | — | WO | disclosed |