Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2230468 | 1.00 | CHRNA7 (0.54) | CHRNA7 | |
| SCHEMBL2228215 | 0.85 | CHRNA7 (0.64) | CHRNA7 | |
| SCHEMBL7281094 | 0.85 | CHRNA7 (0.64) | CHRNA7 | |
| SCHEMBL2228214 | 0.85 | CHRNA7 (0.64) | CHRNA7 | |
| SCHEMBL6884159 | 0.84 | CHRNA7 (0.56) | CHRNA7 | |
| SCHEMBL6881901 | 0.84 | CHRNA7 (0.56) | CHRNA7 | |
| SCHEMBL7697552 | 0.83 | HTR3E (0.53) | CHRNA7 | |
| SCHEMBL373178 | 0.82 | CHRNA7 (0.70) | CHRNA7 | |
| SCHEMBL2229552 | 0.82 | UGCG (0.63) | — | |
| SCHEMBL9443266 | 0.82 | UGCG (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344636-B1 | NOVEL CHIMERIC LIGAND-GATED ION CHANNELS AND METHODS OF USE THEREOF | HUGHES HOWARD MED INST (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-2344636-B1 | NOVEL CHIMERIC LIGAND-GATED ION CHANNELS AND METHODS OF USE THEREOF | HUGHES HOWARD MED INST (US) | 2017-12-06 | — | — | EP | disclosed |
| US-8435762-B2 | Chimeric ligand-gated ion channels and methods of use thereof | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2013-05-07 | — | — | US | disclosed |
| US-8435762-B2 | Chimeric ligand-gated ion channels and methods of use thereof | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2013-05-07 | — | — | US | disclosed |
| US-8435762-B2 | Chimeric ligand-gated ion channels and methods of use thereof | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2013-05-07 | — | — | US | disclosed |
| EP-2344636-A2 | NOVEL CHIMERIC LIGAND-GATED ION CHANNELS AND METHODS OF USE THEREOF | Howard Hughes Medical Institute (US) | 2011-07-20 | — | — | EP | disclosed |
| US-20100130420-A1 | NOVEL CHIMERIC LIGAND-GATED ION CHANNELS AND METHODS OF USE THEREOF | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2010-05-27 | — | — | US | disclosed |
| US-20100130420-A1 | NOVEL CHIMERIC LIGAND-GATED ION CHANNELS AND METHODS OF USE THEREOF | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2010-05-27 | — | — | US | disclosed |
| US-20100130420-A1 | NOVEL CHIMERIC LIGAND-GATED ION CHANNELS AND METHODS OF USE THEREOF | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2010-05-27 | — | — | US | disclosed |
| WO-2010042799-A2 | NOVEL CHIMERIC LIGAND-GATED ION CHANNELS AND METHODS OF USE THEREOF | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130420-A1 | NOVEL CHIMERIC LIGAND-GATED ION CHANNELS AND METHODS OF USE THEREOF | CHRNA7, CHRNA5, CHRNA4 | CHRNA7 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.