Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | ACACA | Q13085 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | LATS1 | O95835 | 2/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30316038 | 1.00 | SCN9A (0.45) | SCN9ACYP17A1BLMACACBACACA | |
| SCHEMBL21224731 | 0.86 | SCN9A (0.52) | SCN9AACACBACACA | |
| SCHEMBL30058851 | 0.84 | HDAC3 (0.57) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL22289979 | 0.84 | HDAC3 (0.57) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL22290558 | 0.84 | BLM (0.46) | BLMABL1EPHX1 | |
| SCHEMBL30060831 | 0.78 | BLM (0.48) | SCN9ACYP17A1BLMABL1 | |
| SCHEMBL22291068 | 0.78 | BLM (0.48) | SCN9ACYP17A1BLMABL1 | |
| SCHEMBL22306187 | 0.77 | AURKA (0.41) | BLMABL1IRAK4 | |
| SCHEMBL22306217 | 0.77 | HDAC3 (0.51) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL23704975 | 0.76 | HTT (0.55) | HDAC3HDAC1HDAC2HDAC10HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020160180-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |