Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 16/20 | 0.44 |
| ▸ | PRKACA | P17612 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | SGK1 | O00141 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
| ▸ | DMPK | Q09013 | 1/20 | 0.40 |
| ▸ | MYLK | Q15746 | 1/20 | 0.40 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22306576 | 0.88 | ROCK1 (0.47) | ROCK1PRKACACYP3A4ROCK2MAPT | |
| SCHEMBL22290324 | 0.85 | SMARCA2 (0.52) | ROCK1PRKACACYP3A4ROCK2MAPT | |
| SCHEMBL22971722 | 0.81 | ROCK1 (0.56) | ROCK1PRKACACYP3A4ROCK2PARP1 | |
| SCHEMBL31173206 | 0.79 | ROCK1 (0.47) | ROCK1PRKACACYP3A4ROCK2MAPT | |
| SCHEMBL22291025 | 0.79 | ROCK1 (0.47) | ROCK1PRKACACYP3A4ROCK2MAPT | |
| SCHEMBL22290647 | 0.79 | PARP1 (0.47) | ROCK1PRKACACYP3A4ROCK2MAPT | |
| SCHEMBL31173242 | 0.79 | PARP1 (0.47) | ROCK1PRKACACYP3A4ROCK2MAPT | |
| SCHEMBL22305346 | 0.79 | MAPT (0.43) | ROCK1PRKACACYP3A4ROCK2MAPT | |
| SCHEMBL22306372 | 0.77 | PARP1 (0.45) | ROCK1PRKACACYP3A4ROCK2MAPT | |
| SCHEMBL22306697 | 0.77 | ROCK1 (0.48) | ROCK1PRKACACYP3A4ROCK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020160180-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |