Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 14/20 | 0.42 |
| ▸ | PRKACA | P17612 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22306576 | 0.90 | ROCK1 (0.47) | MAPTMAPK1ROCK1PRKACACYP3A4 | |
| SCHEMBL22290647 | 0.87 | PARP1 (0.47) | MAPTROCK1PRKACACYP3A4ALDH1A1 | |
| SCHEMBL31173242 | 0.87 | PARP1 (0.47) | MAPTROCK1PRKACACYP3A4ALDH1A1 | |
| SCHEMBL22306610 | 0.84 | ROCK1 (0.48) | MAPTROCK1PRKACACYP3A4ALDH1A1 | |
| SCHEMBL22306581 | 0.83 | HDAC4 (0.51) | MAPTMAPK1ROCK1PRKACACYP3A4 | |
| SCHEMBL22305368 | 0.82 | MAPT (0.49) | MAPTROCK1ALDH1A1ROCK2 | |
| SCHEMBL22305951 | 0.81 | MAPT (0.55) | MAPTMAPK1ALDH1A1PARP1HDAC1 | |
| SCHEMBL22306345 | 0.80 | ROCK2 (0.47) | MAPTMAPK1ROCK1ALDH1A1ROCK2 | |
| SCHEMBL22305714 | 0.80 | WNT3A (0.45) | MAPTMAPK1ROCK1CYP3A4WNT3A | |
| SCHEMBL22306414 | 0.80 | WNT3A (0.54) | ROCK1PRKACACYP3A4WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020160180-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |