Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 13/20 | 0.41 |
| ▸ | CASP6 | P55212 | 10/20 | 0.41 |
| ▸ | CASP8 | Q14790 | 10/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSH | P09668 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18215408 | 0.83 | KDM4E (0.49) | KDM4EALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL22753433 | 0.80 | KDM4E (0.47) | KDM4EALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL12716162 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL3216951 | 0.80 | MAPT (0.50) | KDM4EALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL22307313 | 0.80 | MAPT (0.56) | KDM4EALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL22307835 | 0.79 | MAPT (0.46) | KDM4EALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL12745899 | 0.78 | KDM4E (0.48) | KDM4EALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL22308325 | 0.77 | MAPT (0.49) | KDM4EALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL18678090 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL21361931 | 0.76 | KDM4E (0.47) | KDM4EALDH1A1MAPTHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358940-B2 | K-Ras modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200247762-A1 | K-RAS MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247762-A1 | K-RAS MODULATORS | KRAS, HRAS, NRAS | KDM4E 1414/4885ALDH1A1 3564/4885MAPT 4697/4885 |
| US-11358940-B2 | K-Ras modulators | KRAS, HRAS, NRAS | KDM4E 2440/4885ALDH1A1 3111/4885MAPT 4372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.