SCHEMBL22308196

SCHEMBL22308196

COC(=O)c1cc(N)c(O)c(C#N)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 11/20 0.49
GAA P10253 4/20 0.49
LMNA P02545 3/20 0.49
L3MBTL1 Q9Y468 3/20 0.49
XDH P47989 2/20 0.49
POLB P06746 1/20 0.49
NFKB1 P19838 1/20 0.49
GFER P55789 1/20 0.49
NFKB2 Q00653 1/20 0.49
RELA Q04206 1/20 0.49
FUT7 Q11130 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
USP2 O75604 1/20 0.47
ALDH1A1 P00352 9/20 0.46
HPGD P15428 6/20 0.46
MAPT P10636 5/20 0.46
HSD17B10 Q99714 2/20 0.46
GLA P06280 1/20 0.46
CASP1 P29466 1/20 0.46
CASP7 P55210 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30740886 0.88 KDM4E (0.57) KDM4EGAALMNAL3MBTL1XDH
SCHEMBL9475996 0.83 KDM4E (0.48) KDM4EGAALMNAL3MBTL1XDH
SCHEMBL5924237 0.82 KDM4E (0.63) KDM4EGAALMNAL3MBTL1XDH
SCHEMBL31520153 0.82 KDM4E (0.50) KDM4EGAALMNAL3MBTL1XDH
SCHEMBL32669678 0.82 KDM4E (0.50) KDM4EGAALMNAL3MBTL1XDH
Hydrochloric Acid SCHEMBL9064595 0.81 KDM4E (0.61) KDM4EGAALMNAL3MBTL1XDH
SCHEMBL10323175 0.81 GAA (0.49) KDM4EGAALMNAL3MBTL1XDH
SCHEMBL18031473 0.81 GAA (0.49) KDM4EGAALMNAL3MBTL1XDH
SCHEMBL10322828 0.81 KDM4E (0.49) KDM4EGAALMNAL3MBTL1XDH
SCHEMBL31520159 0.81 KDM4E (0.53) KDM4EGAALMNAL3MBTL1XDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250223286-A1 IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF BETTA PHARMACEUTICALS CO.,LTD (CN) 2025-07-10 US disclosed
CN-113365995-B Immunomodulators, compositions and methods thereof 贝达药业股份有限公司 2025-03-04 CN disclosed
US-12187713-B2 Immunomodulators, compositions and methods thereof BETTA PHARMACEUTICALS CO., LTD (CN) 2025-01-07 US disclosed
CN-115884972-A Immunomodulator, composition and application thereof 贝达药业股份有限公司 2023-03-31 CN disclosed
US-20220098183-A1 IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF BETTA PHARMACEUTICALS CO LTD (CN) 2022-03-31 US disclosed
WO-2022022600-A1 IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF BETTA PHARMACEUTICALS CO., LTD (CN) 2022-02-03 WO disclosed
WO-2022022600-A1 IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF BETTA PHARMACEUTICALS CO., LTD (CN) 2022-02-03 WO disclosed
EP-3917927-A1 IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF Betta Pharmaceuticals Co., Ltd (CN) 2021-12-08 EP disclosed
CN-113365995-A Immunomodulator, composition and method thereof 贝达药业股份有限公司 2021-09-07 CN disclosed
WO-2020156323-A1 IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF BETTA PHARMACEUTICALS CO., LTD (CN) 2020-08-06 WO disclosed
WO-2020156323-A1 IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF BETTA PHARMACEUTICALS CO., LTD (CN) 2020-08-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250223286-A1 IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF IL2, IL5, TSLP KDM4E 3786/4885GAA 1943/4885LMNA 4673/4885
US-20220098183-A1 IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF IL2, TSLP, CD74 KDM4E 4123/4885GAA 2512/4885LMNA 4694/4885
US-12187713-B2 Immunomodulators, compositions and methods thereof IL2, TSLP, CD74 KDM4E 4123/4885GAA 2512/4885LMNA 4694/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.