Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 18/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 18/20 | 0.57 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22309168 | 0.85 | PDE3B (0.53) | PDE3BPDE3AS1PR1S1PR3 | |
| SCHEMBL22308361 | 0.82 | PDE3B (0.56) | PDE3BPDE3A | |
| SCHEMBL22308344 | 0.81 | PDE3B (0.41) | PDE3BPDE3A | |
| SCHEMBL22309165 | 0.80 | PDE3B (0.56) | PDE3BPDE3AS1PR1S1PR3 | |
| SCHEMBL22308893 | 0.78 | PDE3B (0.50) | PDE3BPDE3A | |
| SCHEMBL22309155 | 0.77 | PDE3B (0.47) | PDE3BPDE3A | |
| SCHEMBL22308851 | 0.77 | PDE3B (0.54) | PDE3BPDE3A | |
| SCHEMBL22308343 | 0.76 | PDE3B (0.39) | PDE3BPDE3A | |
| SCHEMBL22307817 | 0.74 | PDE3B (0.62) | PDE3BPDE3A | |
| SCHEMBL22288811 | 0.74 | PDE3B (0.71) | PDE3BPDE3AS1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020157189-A1 | 1,2,4-TRIAZIN-6(1H)-ONE COMPOUNDS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | disclosed |