Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.62 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22308153 | 1.00 | MEN1 (0.70) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL28655445 | 1.00 | MEN1 (0.70) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL22308698 | 1.00 | MEN1 (0.70) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL22289343 | 1.00 | MEN1 (0.70) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL22308690 | 1.00 | MEN1 (0.70) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL22308694 | 1.00 | MEN1 (0.70) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL22308697 | 1.00 | MEN1 (0.70) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL22308695 | 1.00 | MEN1 (0.70) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL8161568 | 0.84 | NPC1 (0.87) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL2979351 | 0.83 | RAB9A (1.00) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020160464-A1 | TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS | MARSHALL UNIVERSITY RESEARCH CORPORATION (US) | 2020-08-06 | — | — | WO | disclosed |