Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6838188 | 0.84 | TSHR (0.45) | TSHRCYP3A4TDP1ATML3MBTL1 | |
| SCHEMBL2230268 | 0.78 | TSHR (0.43) | TSHRCYP3A4TDP1ATML3MBTL1 | |
| SCHEMBL1779633 | 0.77 | CYP3A4 (0.53) | TSHRCYP3A4TDP1ATML3MBTL1 | |
| SCHEMBL5616869 | 0.75 | ALDH1A1 (0.40) | TSHRCYP3A4TDP1ATML3MBTL1 | |
| SCHEMBL21064652 | 0.73 | TSHR (0.61) | TSHRCYP3A4TDP1ATML3MBTL1 | |
| SCHEMBL24983072 | 0.73 | TSHR (0.56) | TSHRCYP3A4TDP1ATML3MBTL1 | |
| SCHEMBL28636947 | 0.72 | CYP3A4 (0.48) | TSHRCYP3A4TDP1ATML3MBTL1 | |
| SCHEMBL2231996 | 0.72 | CYP3A4 (0.48) | TSHRCYP3A4TDP1ATML3MBTL1 | |
| SCHEMBL14161603 | 0.71 | ALDH1A1 (0.48) | TSHRCYP3A4TDP1ATML3MBTL1 | |
| SCHEMBL8217861 | 0.71 | ALDH1A1 (0.52) | TSHRCYP3A4TDP1ATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0447066-B2 | Pneumatic tyres | BRIDGESTONE CORP (JP) | 2000-08-16 | — | — | EP | claimed |
| US-5409969-A | Comprising silica filler, carbon black, silane coupler, living polymer of butadiene-styrene | BRIDGESTONE CORPORATION (JP) | 1995-04-25 | — | — | US | claimed |
| EP-0447066-A1 | Pneumatic tyres | Bridgestone Corporation (JP) | 1991-09-18 | — | — | EP | claimed |
| US-5017636-A | Also containing polyisoprene, natural rubber, butadiene-styrene copolymer, wear and heat resistance, resilience | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1991-05-21 | — | — | US | claimed |
| EP-1721930-B1 | RUBBER COMPOSITION | JSR CORP (JP) | 2015-01-28 | — | — | EP | disclosed |
| US-7981966-B2 | Rubber composition | JSR CORPORATION (JP) | 2011-07-19 | — | — | US | disclosed |
| US-20070208126-A1 | Vulcanizable rubber composition, in particular for low rolling resistance treads of vehicle tires | PIRELLI PNEUMATICI S.P.A. | 2007-09-06 | — | — | US | disclosed |
| US-20070185267-A1 | Rubber composition | JSR CORPORATION (JP) | 2007-08-09 | — | — | US | disclosed |
| EP-1721930-A1 | RUBBER COMPOSITION | JSR Corporation (JP) | 2006-11-15 | — | — | EP | disclosed |
| EP-0992537-B1 | Oil extended rubber and rubber composition | JSR CORP (JP) | 2004-12-29 | — | — | EP | disclosed |
| US-20040220324-A1 | First modified conjugated diolefin-vinylaromatic copolymer; second conjugated diolefin-vinylaromatic copolymer; first carbon black-based reinforcing filler; second silica-based reinforcing filler | PIRELLI PNEUMATICI S.P.A. | 2004-11-04 | — | — | US | disclosed |
| EP-0972790-B1 | Process for producing a vulcanizable rubber composition including carbon black-based and silicia-based reinforcing fillers | PIRELLI (IT) | 2004-09-22 | — | — | EP | disclosed |
| EP-1000970-A1 | Polymodal conjugated diolefin vinyl aromate rubber composition | JSR Corporation (JP) | 2000-05-17 | — | — | EP | disclosed |
| EP-0992537-A1 | Oil extended rubber and rubber composition | JSR Corporation (JP) | 2000-04-12 | — | — | EP | disclosed |
| EP-0972790-A1 | Process for producing a vulcanizable rubber composition including carbon black-based and silicia-based reinforcing fillers | PIRELLI PNEUMATICI Società per Azioni (IT) | 2000-01-19 | — | — | EP | disclosed |
| EP-0934973-A1 | Vulcanizable rubber composition, in particular for low rolling resistance treads of vehicle tires | PIRELLI PNEUMATICI S.p.A. (IT) | 1999-08-11 | — | — | EP | disclosed |
| US-5496883-A | COMPRISING TREAD RUBBER OF POLYBUTADIENE POLYMER OR COPOLYMER CONTAINING SILICA AND MODIFIED WITH SILANE COUPLING AGENT; COUPLING AGENT; WET SKID RESISTANCE, LOW ROLLLING RESISTANCE | BRIDGESTONE CORPORATION (JP) | 1996-03-05 | — | — | US | disclosed |
| US-5409969-A | Comprising silica filler, carbon black, silane coupler, living polymer of butadiene-styrene | BRIDGESTONE CORPORATION (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0447066-A1 | Pneumatic tyres | Bridgestone Corporation (JP) | 1991-09-18 | — | — | EP | disclosed |
| US-5017636-A | Also containing polyisoprene, natural rubber, butadiene-styrene copolymer, wear and heat resistance, resilience | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1991-05-21 | — | — | US | disclosed |