Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.60 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22317365 | 1.00 | PDE3B (0.60) | PDE3BPDE3AGPR119HRH3KCNH2 | |
| SCHEMBL22317372 | 1.00 | PDE3B (0.60) | PDE3BPDE3AGPR119HRH3KCNH2 | |
| SCHEMBL22317772 | 0.89 | PDE3B (0.60) | PDE3BPDE3AGPR119HRH3 | |
| SCHEMBL22317768 | 0.89 | PDE3B (0.60) | PDE3BPDE3AGPR119HRH3 | |
| SCHEMBL22288916 | 0.83 | GPR119 (0.53) | PDE3BPDE3AGPR119HRH3 | |
| SCHEMBL22317770 | 0.80 | PDE3B (0.52) | PDE3BPDE3AGPR119HRH3KCNH2 | |
| SCHEMBL22288535 | 0.80 | PDE3B (0.52) | PDE3BPDE3AGPR119HRH3KCNH2 | |
| SCHEMBL11362311 | 0.78 | HRH3 (0.49) | PDE3BPDE3AGPR119HRH3KCNH2 | |
| SCHEMBL10891315 | 0.76 | PDE3B (0.67) | PDE3BPDE3AGPR119 | |
| SCHEMBL11365384 | 0.75 | HRH3 (0.51) | GPR119HRH3KCNH2ADRA2CSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020157199-A1 | ANNULATED DIHYDROPYRIDAZINONE COMPOUNDS AS ANTI-CANCER COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | disclosed |