Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.51 |
| ▸ | RECQL | P46063 | 3/20 | 0.51 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.51 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.51 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.49 |
| ▸ | F3 | P13726 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1186025 | 1.00 | MAPT (0.55) | MAPTLMNANPC1RAB9AKDM4E | |
| SCHEMBL28949227 | 0.83 | HSP90AA1 (0.55) | MAPTLMNANPC1RAB9AKDM4E | |
| SCHEMBL3363377 | 0.81 | CYP1A2 (0.59) | MAPTLMNANPC1RAB9ACYP1B1 | |
| SCHEMBL3363379 | 0.81 | CYP1A2 (0.59) | MAPTLMNANPC1RAB9ACYP1B1 | |
| SCHEMBL7670441 | 0.81 | NPC1 (0.52) | MAPTLMNANPC1RAB9AKDM4E | |
| SCHEMBL20746436 | 0.80 | KMT2A (0.51) | MAPTLMNANPC1RAB9ABCHE | |
| SCHEMBL20746435 | 0.80 | KMT2A (0.51) | MAPTLMNANPC1RAB9ABCHE | |
| SCHEMBL7663059 | 0.79 | NPC1 (0.44) | MAPTLMNANPC1RAB9AKDM4E | |
| SCHEMBL20754590 | 0.79 | CYP2D6 (0.39) | MAPTLMNANPC1RAB9AKDM4E | |
| SCHEMBL7661505 | 0.74 | MAPT (0.51) | MAPTLMNANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104822676-B | Novel ROCK inhibitors | PH制药有限公司 | 2019-11-05 | — | — | CN | disclosed |
| EP-2914590-B1 | NOVEL ROCK INHIBITORS | PH PHARMA CO LTD (KR) | 2016-11-30 | — | — | EP | disclosed |
| US-9394286-B2 | Rock inhibitors | AMAKEM NV (BE) | 2016-07-19 | — | — | US | disclosed |
| CN-105154418-A | Compositions and methods comprising a subtilisin variant | DANISCO US INC | 2015-12-16 | — | — | CN | disclosed |
| US-9174939-B2 | Soft rock inhibitors | AMAKEM NV (BE) | 2015-11-03 | — | — | US | disclosed |
| EP-2751080-B1 | NOVEL SOFT ROCK INHIBITORS | AMAKEM NV (BE) | 2015-10-28 | — | — | EP | disclosed |
| US-20150299173-A1 | NOVEL ROCK INHIBTORS | AMAKEM NV (BE) | 2015-10-22 | — | — | US | disclosed |
| EP-2914590-A1 | NOVEL ROCK INHIBITORS | Amakem NV (BE) | 2015-09-09 | — | — | EP | disclosed |
| US-9126933-B2 | Soft PDE4 inhibitors | AMAKEM NV (BE) | 2015-09-08 | — | — | US | disclosed |
| CN-104822676-A | Novel ROCK inhibitors | AMAKEM NV | 2015-08-05 | — | — | CN | disclosed |
| US-5739170-A | PARASITICIDE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-04-14 | — | — | US | disclosed |
| EP-0817624-A1 | INHIBITORS OF METAZOAN PARASITE PROTEASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-01-14 | — | — | EP | disclosed |
| CN-1152910-A | Difluorostatone antiviral agents | MERRELL PHARMA INC (US) | 1997-06-25 | — | — | CN | disclosed |
| WO-1996030004-A1 | INHIBITORS OF METAZOAN PARASITE PROTEASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-10-03 | — | — | WO | disclosed |
| EP-0581165-A2 | Acrylamide derivatives as antirussive agent | DOMPE' FARMACEUTICI S.p.A. (IT) | 1994-02-02 | — | — | EP | disclosed |
| US-4634628-A | Recording medium and image recording process | CANON KABUSHIKI KAISHA (JP) | 1987-01-06 | — | — | US | disclosed |
| US-4610997-A | Fungicidal N-acylimidazoles | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1986-09-09 | — | — | US | disclosed |
| EP-0141619-A2 | N-Acylimidazoles and their production and use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1985-05-15 | — | — | EP | disclosed |
| US-4493842-A | Fungicidal N-(phenyl-lower alkanoyl-)-imidazole derivatives, composition, and method of use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1985-01-15 | — | — | US | disclosed |
| EP-0095285-A1 | N-acylimidazoles, their production and use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-11-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299173-A1 | NOVEL ROCK INHIBTORS | ROCK1, ROCK2, CIT | MAPT 1809/4885LMNA 3528/4885NPC1 4074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.