Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 12/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 11/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 10/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22320574 | 1.00 | HRH3 (0.44) | HRH3IRAK4EPHA2HDAC1HDAC8 | |
| SCHEMBL22262485 | 0.94 | HRH3 (0.39) | HRH3IRAK4EPHA2PDK1 | |
| SCHEMBL22262484 | 0.94 | HRH3 (0.39) | HRH3IRAK4EPHA2PDK1 | |
| SCHEMBL22320756 | 0.87 | HRH3 (0.45) | HRH3IRAK4EPHA2KDREPHB4 | |
| SCHEMBL22320757 | 0.87 | HRH3 (0.45) | HRH3IRAK4EPHA2KDREPHB4 | |
| SCHEMBL22320559 | 0.85 | PDK1 (0.41) | HRH3IRAK4EPHA2KDREPHB4 | |
| SCHEMBL22320561 | 0.85 | PDK1 (0.41) | HRH3IRAK4EPHA2KDREPHB4 | |
| SCHEMBL22262538 | 0.84 | HRH3 (0.49) | HRH3IRAK4HDAC1HDAC8HDAC6 | |
| SCHEMBL22320687 | 0.83 | HRH3 (0.48) | HRH3IRAK4EPHA2KDREPHB4 | |
| SCHEMBL22320690 | 0.83 | HRH3 (0.48) | HRH3IRAK4EPHA2KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112739343-A | Macrocyclic MCL-1 inhibitors and methods of use | 艾伯维公司 | 2021-04-30 | — | — | CN | disclosed |
| US-20200255451-A1 | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE | ABBVIE INC (US) | 2020-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255451-A1 | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE | MCL1, BCL2A1, BCL2L10 | HRH3 3652/4885IRAK4 1361/4885EPHA2 2661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.