Silver — predicted protein targets

Known targets — ChEMBL curated mechanism

The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 4)

	gene	UniProt	supporting neighbours	confidence
▸	ALDH1A1	P00352	1/20	0.48

▸	NPSR1	Q6W5P4	1/20	0.31

▸	BCHE	P06276	2/20	0.30

▸	ACHE	P22303	2/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2015730	0.81	ALDH1A1 (0.50)	ALDH1A1BCHEACHE
SCHEMBL4737789	0.79	ALDH1A1 (0.48)	ALDH1A1BCHEACHE
SCHEMBL2010219	0.79	ALDH1A1 (0.48)	ALDH1A1BCHEACHE
SCHEMBL10157896	0.79	ALDH1A1 (0.48)	ALDH1A1BCHEACHE
SCHEMBL2015296	0.78	ALDH1A1 (0.46)	ALDH1A1NPSR1BCHEACHE
SCHEMBL14163142	0.76	ALDH1A1 (0.45)	ALDH1A1
SCHEMBL2014486	0.75	ALDH1A1 (0.43)	ALDH1A1
SCHEMBL7768788	0.74	ALDH1A1 (0.52)	ALDH1A1
Potassium Ion SCHEMBL7774839	0.74	ALDH1A1 (0.52)	ALDH1A1
SCHEMBL9499979	0.73	ALDH1A1 (0.38)	ALDH1A1BCHEACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2011092065-A1	NITRIC OXIDE RELEASING COMPOUNDS FOR THE TREATMENT OF NEUROPHATIC PAIN	NICOX S.A. (FR)	2011-08-04	—	—	WO	disclosed