Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844069 | 0.93 | PRSS1 (0.52) | PRSS1PRSS2PRSS3MMP2MMP9 | |
| SCHEMBL20314640 | 0.82 | KMT2A (0.61) | MMP2MMP9MMP8HDAC2KMT2A | |
| SCHEMBL679970 | 0.82 | MKNK1 (0.56) | PRSS1PRSS2PRSS3MMP2MMP9 | |
| SCHEMBL11310791 | 0.82 | MKNK1 (0.56) | PRSS1PRSS2PRSS3MMP2MMP9 | |
| SCHEMBL5712083 | 0.82 | SMN1; SMN2 (0.48) | HSD17B1MAPTSMN1; SMN2 | |
| SCHEMBL4623255 | 0.75 | EGFR (0.48) | MKNK1MKNK2TSHRKIF11HDAC2 | |
| SCHEMBL258820 | 0.75 | MAP2K4 (0.49) | MKNK1MKNK2TSHRKIF11HDAC2 | |
| SCHEMBL3641834 | 0.74 | RARB (0.58) | TSHRKMT2ARARBEPHX2MAPT | |
| SCHEMBL1286664 | 0.73 | KMT2A (0.70) | PRSS1PRSS2PRSS3KMT2AEPHX2 | |
| SCHEMBL1066908 | 0.73 | PRSS1 (0.48) | PRSS1PRSS2PRSS3MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3920912-A1 | TREATMENT OF CILIOPATHIES USING INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE (GCS) | Genzyme Corporation (US) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020163337-A1 | TREATMENT OF CILIOPATHIES USING INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE (GCS) | GENZYME CORPORATION (US) | 2020-08-13 | — | — | WO | disclosed |