Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Varenicline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 known ✓ | P17787 | 10/20 | 0.71 |
| ▸ | CHRNA4 known ✓ | P43681 | 10/20 | 0.71 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.71 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.71 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.71 |
| ▸ | CHRNG | P07510 | 2/20 | 0.71 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.71 |
| ▸ | CHRND | Q07001 | 2/20 | 0.71 |
| ▸ | ESR1 | P03372 | 1/20 | 0.71 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.71 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.71 |
| ▸ | HTR3A | P46098 | 1/20 | 0.71 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Varenicline SCHEMBL29761222 | 1.00 | CHRNB2 (0.71) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| Varenicline SCHEMBL224851 | 1.00 | CHRNB2 (0.71) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| Varenicline SCHEMBL31413925 | 1.00 | CHRNB2 (0.71) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| Varenicline SCHEMBL29761223 | 1.00 | CHRNB2 (0.71) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| Varenicline SCHEMBL224852 | 1.00 | CHRNB2 (0.71) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| Varenicline SCHEMBL23510345 | 0.88 | CHRNB2 (0.80) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| Varenicline SCHEMBL137144 | 0.84 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| Varenicline SCHEMBL5959022 | 0.84 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| Varenicline SCHEMBL225687 | 0.84 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| Varenicline SCHEMBL29710884 | 0.84 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11918588-B2 | Neuronal nicotinic acetylcholine receptor partial agonists as therapeutics for chronic tinnitus | BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY (US) | 2024-03-05 | — | — | US | claimed |
| WO-2023182957-A1 | REPURPOSING VARENICLINE AS AN ANTI-INFLAMMATORY AGENT WITH ITS SUPPRESSOR EFFECTS ON INFLAMMATORY CYTOKINES | İZMİR EKONOMİ ÜNİVERSİTESİ (TR) | 2023-09-28 | — | — | WO | claimed |
| WO-2020163588-A1 | NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR PARTIAL AGONISTS AS THERAPEUTICS FOR CHRONIC TINNITUS | BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY (US) | 2020-08-13 | — | — | WO | claimed |
| US-11918588-B2 | Neuronal nicotinic acetylcholine receptor partial agonists as therapeutics for chronic tinnitus | BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY (US) | 2024-03-05 | — | — | US | disclosed |
| WO-2023182957-A1 | REPURPOSING VARENICLINE AS AN ANTI-INFLAMMATORY AGENT WITH ITS SUPPRESSOR EFFECTS ON INFLAMMATORY CYTOKINES | İZMİR EKONOMİ ÜNİVERSİTESİ (TR) | 2023-09-28 | — | — | WO | disclosed |
| WO-2020163588-A1 | NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR PARTIAL AGONISTS AS THERAPEUTICS FOR CHRONIC TINNITUS | BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY (US) | 2020-08-13 | — | — | WO | disclosed |